Title |
Fibronectin coating of oxygenator membranes enhances endothelial cell attachment
|
---|---|
Published in |
BioMedical Engineering OnLine, January 2013
|
DOI | 10.1186/1475-925x-12-7 |
Pubmed ID | |
Authors |
Christian G Cornelissen, Maren Dietrich, Kai Gromann, Julia Frese, Stefan Krueger, Jörg S Sachweh, Stefan Jockenhoevel |
Abstract |
Extracorporeal membrane oxygenation (ECMO) can replace the lungs' gas exchange capacity in refractory lung failure. However, its limited hemocompatibility, the activation of the coagulation and complement system as well as plasma leakage and protein deposition hamper mid- to long-term use and have constrained the development of an implantable lung assist device. In a tissue engineering approach, lining the blood contact surfaces of the ECMO device with endothelial cells might overcome these limitations. As a first step towards this aim, we hypothesized that coating the oxygenator's gas exchange membrane with proteins might positively influence the attachment and proliferation of arterial endothelial cells. |
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Mendeley readers
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