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The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases

Overview of attention for article published in Particle and Fibre Toxicology, September 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Citations

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230 Dimensions

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160 Mendeley
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Title
The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases
Published in
Particle and Fibre Toxicology, September 2016
DOI 10.1186/s12989-016-0162-4
Pubmed ID
Authors

Mutlay Sayan, Brooke T. Mossman

Abstract

The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres. Most notably, inflammasome activation appears to regulate the balance between tissue repair and inflammation after inhalation of pathogenic pollutants such as asbestos, crystalline silica (CS), and airborne particulate matter (PM). Different types of fibres and particles may have distinct mechanisms of inflammasome interaction and outcome. This review summarizes the structure and function of inflammasomes, the interplay between various chemokines and cytokines and cell types of the lung and pleura after inflammasome activation, and the events leading to the development of non-malignant (allergic airway disease and chronic obstructive pulmonary disease (COPD), asbestosis, silicosis) and malignant (mesothelioma, lung cancer) diseases by pathogenic particulates. In addition, it emphasizes the importance of communication between cells of the immune system, target cells of these diseases, and components of the extracellular matrix (ECM) in regulation of inflammasome-mediated events.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 <1%
Unknown 159 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 14%
Student > Bachelor 19 12%
Student > Ph. D. Student 18 11%
Researcher 17 11%
Student > Doctoral Student 9 6%
Other 28 18%
Unknown 47 29%
Readers by discipline Count As %
Medicine and Dentistry 32 20%
Biochemistry, Genetics and Molecular Biology 20 13%
Pharmacology, Toxicology and Pharmaceutical Science 13 8%
Agricultural and Biological Sciences 10 6%
Immunology and Microbiology 7 4%
Other 21 13%
Unknown 57 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2019.
All research outputs
#6,981,149
of 22,889,074 outputs
Outputs from Particle and Fibre Toxicology
#218
of 561 outputs
Outputs of similar age
#105,691
of 320,233 outputs
Outputs of similar age from Particle and Fibre Toxicology
#5
of 20 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 561 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.