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The human microbiome and juvenile idiopathic arthritis

Overview of attention for article published in Pediatric Rheumatology, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog
twitter
15 X users
googleplus
1 Google+ user

Citations

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29 Dimensions

Readers on

mendeley
130 Mendeley
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Title
The human microbiome and juvenile idiopathic arthritis
Published in
Pediatric Rheumatology, September 2016
DOI 10.1186/s12969-016-0114-4
Pubmed ID
Authors

Anouk Verwoerd, Nienke M. Ter Haar, Sytze de Roock, Sebastiaan J. Vastert, Debby Bogaert

Abstract

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers. However, the precise factors that determine one's susceptibility to JIA remain to be unravelled. The microbiome has received increasing attention as a potential contributing factor to the development of a wide array of immune-mediated diseases, including inflammatory bowel disease, type 1 diabetes and rheumatoid arthritis. Also in JIA, there is accumulating evidence that the composition of the microbiome is different from healthy individuals. A growing body of evidence indeed suggests that, among others, the microbiome may influence the development of the immune system, the integrity of the intestinal mucosal barrier, and the differentiation of T cell subsets. In turn, this might lead to dysregulation of the immune system, thereby possibly playing a role in the development of JIA. The potential to manipulate the microbiome, for example by faecal microbial transplantation, might then offer perspectives for future therapeutic interventions. Before we can think of such interventions, we need to first obtain a deeper understanding of the cause and effect relationship between JIA and the microbiome. In this review, we discuss the existing evidence for the involvement of the microbiome in JIA pathogenesis and explore the potential mechanisms through which the microbiome may influence the development of autoimmunity in general and JIA specifically.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 130 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 16%
Researcher 15 12%
Student > Bachelor 13 10%
Student > Ph. D. Student 12 9%
Student > Doctoral Student 10 8%
Other 27 21%
Unknown 32 25%
Readers by discipline Count As %
Medicine and Dentistry 43 33%
Biochemistry, Genetics and Molecular Biology 14 11%
Agricultural and Biological Sciences 9 7%
Immunology and Microbiology 9 7%
Nursing and Health Professions 6 5%
Other 14 11%
Unknown 35 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2018.
All research outputs
#2,070,158
of 23,870,022 outputs
Outputs from Pediatric Rheumatology
#58
of 740 outputs
Outputs of similar age
#36,533
of 323,983 outputs
Outputs of similar age from Pediatric Rheumatology
#2
of 10 outputs
Altmetric has tracked 23,870,022 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 740 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.