Title |
Repeat-encoded poly-Q tracts show statistical commonalities across species
|
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Published in |
BMC Genomics, February 2013
|
DOI | 10.1186/1471-2164-14-76 |
Pubmed ID | |
Authors |
Kai Willadsen, Minh Duc Cao, Janet Wiles, Sureshkumar Balasubramanian, Mikael Bodén |
Abstract |
Among repetitive genomic sequence, the class of tri-nucleotide repeats has received much attention due to their association with human diseases. Tri-nucleotide repeat diseases are caused by excessive sequence length variability; diseases such as Huntington's disease and Fragile X syndrome are tied to an increase in the number of repeat units in a tract. Motivated by the recent discovery of a tri-nucleotide repeat associated genetic defect in Arabidopsis thaliana, this study takes a cross-species approach to investigating these repeat tracts, with the goal of using commonalities between species to identify potential disease-related properties. |
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