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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Goat K222-PrPC polymorphic variant does not provide resistance to atypical scrapie in transgenic mice
|
|---|---|
| Published in |
Veterinary Research, September 2016
|
| DOI | 10.1186/s13567-016-0380-7 |
| Pubmed ID | |
| Authors |
Patricia Aguilar-Calvo, Juan-Carlos Espinosa, Olivier Andréoletti, Lorenzo González, Leonor Orge, Ramón Juste, Juan-María Torres |
| Abstract |
Host prion (PrP(C)) genotype is a major determinant for the susceptibility to prion diseases. The Q/K222-PrP(C) polymorphic variant provides goats and mice with high resistance against classical scrapie and bovine spongiform encephalopathy (BSE); yet its effect against atypical scrapie is unknown. Here, transgenic mice expressing the goat wild-type (wt) or the K222-PrP(C) variant were intracerebrally inoculated with several natural cases of atypical scrapie from sheep and goat and their susceptibility to the prion disease was determined. Goat wt and K222-PrP(C) transgenic mice were 100% susceptible to all the atypical scrapie isolates, showing similar survival times and almost identical disease phenotypes. The capacity of the K222-PrP(C) variant to replicate specifically the atypical scrapie strain as efficiently as the goat wt PrP(C), but not the classical scrapie or cattle-BSE as previously reported, further suggests the involvement of concrete areas of the host PrP(C) in the strain-dependent replication of prions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 29% |
| Student > Bachelor | 2 | 12% |
| Student > Master | 2 | 12% |
| Other | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 3 | 18% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 29% |
| Veterinary Science and Veterinary Medicine | 4 | 24% |
| Biochemistry, Genetics and Molecular Biology | 2 | 12% |
| Nursing and Health Professions | 1 | 6% |
| Medicine and Dentistry | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 4 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2016.
All research outputs
#2,811,067
of 25,373,627 outputs
Outputs from Veterinary Research
#97
of 1,337 outputs
Outputs of similar age
#46,078
of 328,637 outputs
Outputs of similar age from Veterinary Research
#3
of 24 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.