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Mendeley readers
Attention Score in Context
| Title |
Origin and evolution of the RIG-I like RNA helicase gene family
|
|---|---|
| Published in |
BMC Ecology and Evolution, April 2009
|
| DOI | 10.1186/1471-2148-9-85 |
| Pubmed ID | |
| Authors |
Jun Zou, Mingxian Chang, Pin Nie, Chris J Secombes |
| Abstract |
The DExD/H domain containing RNA helicases such as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are key cytosolic pattern recognition receptors (PRRs) for detecting nucleotide pathogen associated molecular patterns (PAMPs) of invading viruses. The RIG-I and MDA5 proteins differentially recognise conserved PAMPs in double stranded or single stranded viral RNA molecules, leading to activation of the interferon system in vertebrates. They share three core protein domains including a RNA helicase domain near the C terminus (HELICc), one or more caspase activation and recruitment domains (CARDs) and an ATP dependent DExD/H domain. The RIG-I/MDA5 directed interferon response is negatively regulated by laboratory of genetics and physiology 2 (LGP2) and is believed to be controlled by the mitochondria antiviral signalling protein (MAVS), a CARD containing protein associated with mitochondria. |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 2 | 1% |
| India | 2 | 1% |
| United Kingdom | 2 | 1% |
| Spain | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 134 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 34% |
| Researcher | 26 | 18% |
| Student > Master | 13 | 9% |
| Student > Doctoral Student | 11 | 8% |
| Student > Bachelor | 8 | 6% |
| Other | 21 | 14% |
| Unknown | 17 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 67 | 46% |
| Biochemistry, Genetics and Molecular Biology | 27 | 19% |
| Immunology and Microbiology | 11 | 8% |
| Medicine and Dentistry | 6 | 4% |
| Computer Science | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 20 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#5,446,210
of 25,371,288 outputs
Outputs from BMC Ecology and Evolution
#1,318
of 3,714 outputs
Outputs of similar age
#20,592
of 104,052 outputs
Outputs of similar age from BMC Ecology and Evolution
#13
of 46 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.