↓ Skip to main content

Origin and evolution of the RIG-I like RNA helicase gene family

Overview of attention for article published in BMC Evolutionary Biology, January 2009
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
202 Dimensions

Readers on

mendeley
134 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Origin and evolution of the RIG-I like RNA helicase gene family
Published in
BMC Evolutionary Biology, January 2009
DOI 10.1186/1471-2148-9-85
Pubmed ID
Authors

Jun Zou, Mingxian Chang, Pin Nie, Chris J Secombes

Abstract

The DExD/H domain containing RNA helicases such as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are key cytosolic pattern recognition receptors (PRRs) for detecting nucleotide pathogen associated molecular patterns (PAMPs) of invading viruses. The RIG-I and MDA5 proteins differentially recognise conserved PAMPs in double stranded or single stranded viral RNA molecules, leading to activation of the interferon system in vertebrates. They share three core protein domains including a RNA helicase domain near the C terminus (HELICc), one or more caspase activation and recruitment domains (CARDs) and an ATP dependent DExD/H domain. The RIG-I/MDA5 directed interferon response is negatively regulated by laboratory of genetics and physiology 2 (LGP2) and is believed to be controlled by the mitochondria antiviral signalling protein (MAVS), a CARD containing protein associated with mitochondria.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 1%
India 2 1%
United Kingdom 2 1%
Spain 1 <1%
Switzerland 1 <1%
Unknown 123 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 36%
Researcher 25 19%
Student > Master 13 10%
Student > Doctoral Student 10 7%
Student > Bachelor 8 6%
Other 21 16%
Unknown 9 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 68 51%
Biochemistry, Genetics and Molecular Biology 25 19%
Immunology and Microbiology 11 8%
Medicine and Dentistry 6 4%
Physics and Astronomy 3 2%
Other 10 7%
Unknown 11 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#3,488,166
of 17,361,274 outputs
Outputs from BMC Evolutionary Biology
#959
of 2,801 outputs
Outputs of similar age
#49,193
of 255,461 outputs
Outputs of similar age from BMC Evolutionary Biology
#69
of 221 outputs
Altmetric has tracked 17,361,274 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,801 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 221 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.