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Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

Overview of attention for article published in Molecular Cancer, February 2013
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Title
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer
Published in
Molecular Cancer, February 2013
DOI 10.1186/1476-4598-12-9
Pubmed ID
Authors

Yuanyuan Li, Syed M Meeran, Shweta N Patel, Huaping Chen, Tabitha M Hardy, Trygve O Tollefsbol

Abstract

Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies. The soybean isoflavone, genistein (GE), has been shown to prevent and inhibit breast cancer and recent studies have suggested that GE can enhance the anticancer capacity of an estrogen antagonist, tamoxifen (TAM), especially in ERα-positive breast cancer cells. However, the role of GE in ERα-negative breast cancer remains unknown.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Indonesia 1 <1%
Chile 1 <1%
Canada 1 <1%
Unknown 106 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 15%
Researcher 16 14%
Student > Master 16 14%
Student > Bachelor 14 13%
Student > Doctoral Student 6 5%
Other 23 21%
Unknown 19 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 23%
Biochemistry, Genetics and Molecular Biology 22 20%
Medicine and Dentistry 20 18%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Chemistry 3 3%
Other 14 13%
Unknown 21 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2013.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Molecular Cancer
#1,480
of 1,918 outputs
Outputs of similar age
#230,041
of 291,530 outputs
Outputs of similar age from Molecular Cancer
#12
of 15 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,530 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.