↓ Skip to main content

Adjuvants for peptide-based cancer vaccines

Overview of attention for article published in Journal for Immunotherapy of Cancer, September 2016
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)

Mentioned by

twitter
5 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
85 Dimensions

Readers on

mendeley
165 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Adjuvants for peptide-based cancer vaccines
Published in
Journal for Immunotherapy of Cancer, September 2016
DOI 10.1186/s40425-016-0160-y
Pubmed ID
Authors

Hiep Khong, Willem W. Overwijk

Abstract

Cancer therapies based on T cells have shown impressive clinical benefit. In particular, immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing dramatic tumor shrinkage and prolonged patient survival in a variety of cancers. However, many patients do not benefit, possibly due to insufficient spontaneous T cell reactivity against their tumors and/or lacking immune cell infiltration to tumor site. Such tumor-specific T cell responses could be induced through anti-cancer vaccination; but despite great success in animal models, only a few of many cancer vaccine trials have demonstrated robust clinical benefit. One reason for this difference may be the use of potent, effective vaccine adjuvants in animal models, vs. the use of safe, but very weak, vaccine adjuvants in clinical trials. As vaccine adjuvants dictate the type and magnitude of the T cell response after vaccination, it is critical to understand how they work to design safe, but also effective, cancer vaccines for clinical use. Here we discuss current insights into the mechanism of action and practical application of vaccine adjuvants, with a focus on peptide-based cancer vaccines.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 164 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 34 21%
Student > Ph. D. Student 32 19%
Student > Bachelor 25 15%
Student > Master 17 10%
Student > Doctoral Student 11 7%
Other 18 11%
Unknown 28 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 20%
Immunology and Microbiology 32 19%
Agricultural and Biological Sciences 18 11%
Medicine and Dentistry 18 11%
Chemistry 8 5%
Other 22 13%
Unknown 34 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2017.
All research outputs
#6,234,597
of 19,196,842 outputs
Outputs from Journal for Immunotherapy of Cancer
#1,201
of 2,110 outputs
Outputs of similar age
#101,477
of 279,408 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#2
of 2 outputs
Altmetric has tracked 19,196,842 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,110 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.