Title |
Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya
|
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Published in |
Malaria Journal, November 2010
|
DOI | 10.1186/1475-2875-9-338 |
Pubmed ID | |
Authors |
Maroya D Spalding, Fredrick L Eyase, Hoseah M Akala, Sheryl A Bedno, Sean T Prigge, Rodney L Coldren, William J Moss, Norman C Waters |
Abstract |
Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ) as the first-line anti-malarial in 1998 and artemether-lumefantrine (AL) replaced SP in 2004. Two cross-sectional studies were conducted to monitor changes in the prevalence of molecular markers of drug resistance over the period in which SP was used as the first-line anti-malarial. The baseline study was carried out from 1999-2000, shortly after implementation of SP, and the follow-up study occurred from 2003-2005, during the transition to AL. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Burkina Faso | 2 | 3% |
United Kingdom | 2 | 3% |
Pakistan | 1 | 1% |
Unknown | 66 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 15 | 21% |
Student > Ph. D. Student | 13 | 18% |
Researcher | 7 | 10% |
Other | 5 | 7% |
Student > Bachelor | 4 | 6% |
Other | 14 | 20% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 27% |
Medicine and Dentistry | 14 | 20% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Social Sciences | 3 | 4% |
Other | 5 | 7% |
Unknown | 18 | 25% |