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Attention Score in Context
| Title |
Host cytoskeleton in respiratory syncytial virus assembly and budding
|
|---|---|
| Published in |
Virology Journal, September 2016
|
| DOI | 10.1186/s12985-016-0618-z |
| Pubmed ID | |
| Authors |
Shadi Shahriari, James Gordon, Reena Ghildyal |
| Abstract |
Respiratory syncytial virus (RSV) is one of the major pathogens responsible for lower respiratory tract infections (LRTI) in young children, the elderly, and the immunosuppressed. Currently, there are no antiviral drugs or vaccines available that effectively target RSV infections, proving a significant challenge in regards to prevention and treatment. An in-depth understanding of the host-virus interactions that underlie assembly and budding would inform new targets for antiviral development.Current research suggests that the polymerised form of actin, the filamentous or F-actin, plays a role in RSV assembly and budding. Treatment with cytochalasin D, which disrupts F-actin, has been shown to inhibit virus release. In addition, the actin cytoskeleton has been shown to interact with the RSV matrix (M) protein, which plays a central role in RSV assembly. For this reason, the interaction between these two components is hypothesised to facilitate the movement of viral components in the cytoplasm and to the budding site. Despite increases in our knowledge of RSV assembly and budding, M-actin interactions are not well understood. In this review, we discuss the current literature on the role of actin cytoskeleton during assembly and budding of RSV with the aim to integrate disparate studies to build a hypothetical model of the various molecular interactions between actin and RSV M protein that facilitate RSV assembly and budding. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 18% |
| Student > Master | 18 | 17% |
| Student > Bachelor | 14 | 13% |
| Researcher | 9 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Other | 11 | 10% |
| Unknown | 31 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 20% |
| Biochemistry, Genetics and Molecular Biology | 19 | 18% |
| Immunology and Microbiology | 13 | 12% |
| Chemistry | 5 | 5% |
| Medicine and Dentistry | 4 | 4% |
| Other | 8 | 7% |
| Unknown | 37 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2016.
All research outputs
#18,472,072
of 22,889,074 outputs
Outputs from Virology Journal
#2,446
of 3,052 outputs
Outputs of similar age
#245,215
of 322,700 outputs
Outputs of similar age from Virology Journal
#34
of 44 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.