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Treatment targets in systemic lupus erythematosus: biology and clinical perspective

Overview of attention for article published in Arthritis Research & Therapy, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
2 blogs
facebook
1 Facebook page

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
56 Mendeley
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Title
Treatment targets in systemic lupus erythematosus: biology and clinical perspective
Published in
Arthritis Research & Therapy, January 2012
DOI 10.1186/ar3917
Pubmed ID
Authors

Valentin Marian, Jennifer H Anolik

Abstract

Systemic lupus erythematosus (SLE) is a complex disease characterized by numerous autoantibodies and clinical involvement in multiple organ systems. The immunological events triggering the onset and progression of clinical manifestations are also complex and multi-step, including breach of tolerance in the adaptive immune system, amplification of autoimmunity through innate and adaptive immune system dysregulation, and end-organ damage. Studies of murine genetic manipulations and human risk variants have provided important clues to the cellular and molecular pathogenesis of SLE, operating at multiple of these steps. The breakdown of B-cell tolerance is probably a defining and early event in the disease process and may occur by multiple pathways, including alterations in factors that affect B-cell activation thresholds, B-cell longevity, and apoptotic cell processing. Examples of amplification of autoimmunity on the adaptive immune system side include disturbances in B-cell/T-cell collaboration. B cells can also amplify innate immune cell activation via antibody-dependent and antibody-independent mechanisms. Indeed, one of the key amplification loops in SLE is the activation of plasmacytoid dendritic cells via autoantibodies and RNA-containing and DNA-containing immune complexes, which act as Toll-like receptor ligands, stimulating the secretion of large quantities of IFNα. A more recent link between the innate and adaptive immune system in SLE includes the neutrophil, which can be primed by interferon and autoantibodies to release neutrophil extracellular traps as an additional source of immunogenic DNA, histones, and neutrophil proteins. The innate immune system activation then feeds back, driving autoreactive B-cell and T-cell survival and maturation. This self-perpetuating disease cycle creates the opportunity for targeted treatment inventions at multiple steps.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Italy 1 2%
Brazil 1 2%
Israel 1 2%
Spain 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 29%
Student > Bachelor 12 21%
Other 5 9%
Student > Ph. D. Student 4 7%
Student > Postgraduate 4 7%
Other 10 18%
Unknown 5 9%
Readers by discipline Count As %
Medicine and Dentistry 21 38%
Agricultural and Biological Sciences 15 27%
Biochemistry, Genetics and Molecular Biology 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Immunology and Microbiology 3 5%
Other 2 4%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2014.
All research outputs
#1,776,631
of 16,578,610 outputs
Outputs from Arthritis Research & Therapy
#388
of 2,498 outputs
Outputs of similar age
#25,892
of 252,854 outputs
Outputs of similar age from Arthritis Research & Therapy
#14
of 164 outputs
Altmetric has tracked 16,578,610 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,498 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,854 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.