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Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis

Overview of attention for article published in BMC Neuroscience, February 2013
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Title
Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis
Published in
BMC Neuroscience, February 2013
DOI 10.1186/1471-2202-14-19
Pubmed ID
Authors

Márcia Carvalho Vilela, Graciela Kunrath Lima, David Henrique Rodrigues, Norinne Lacerda-Queiroz, Vinicius Sousa Pietra Pedroso, Aline Silva Miranda, Milene Alvarenga Rachid, Erna Geessien Kroon, Marco Antônio Campos, Mauro Martins Teixeira, Johann Sellner, Antonio Lucio Teixeira

Abstract

The neuroinflammatory response aimed at clearance of herpes simplex virus-1 (HSV-1) plays a key role in the pathogenesis of neuroaxonal damage in herpetic encephalitis. Leukocytes activated in an adaptive immune response access brain tissue by passing through the blood-brain barrier. The chemokine CCL5/RANTES is involved in recruitment of these cells to the brain acting via the receptors CCR1, CCR3 and mainly CCR5. Here, we evaluated the role of CCR5 on traffic of leukocytes in the brain microvasculature, cellular and cytokines profile in a severe form of herpetic encephalitis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 33%
Student > Master 3 14%
Other 2 10%
Lecturer 1 5%
Professor 1 5%
Other 3 14%
Unknown 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 24%
Immunology and Microbiology 4 19%
Biochemistry, Genetics and Molecular Biology 2 10%
Medicine and Dentistry 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 1 5%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2013.
All research outputs
#20,182,546
of 22,696,971 outputs
Outputs from BMC Neuroscience
#1,051
of 1,240 outputs
Outputs of similar age
#249,693
of 282,966 outputs
Outputs of similar age from BMC Neuroscience
#26
of 36 outputs
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So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.