Title |
Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis
|
---|---|
Published in |
BMC Neuroscience, February 2013
|
DOI | 10.1186/1471-2202-14-19 |
Pubmed ID | |
Authors |
Márcia Carvalho Vilela, Graciela Kunrath Lima, David Henrique Rodrigues, Norinne Lacerda-Queiroz, Vinicius Sousa Pietra Pedroso, Aline Silva Miranda, Milene Alvarenga Rachid, Erna Geessien Kroon, Marco Antônio Campos, Mauro Martins Teixeira, Johann Sellner, Antonio Lucio Teixeira |
Abstract |
The neuroinflammatory response aimed at clearance of herpes simplex virus-1 (HSV-1) plays a key role in the pathogenesis of neuroaxonal damage in herpetic encephalitis. Leukocytes activated in an adaptive immune response access brain tissue by passing through the blood-brain barrier. The chemokine CCL5/RANTES is involved in recruitment of these cells to the brain acting via the receptors CCR1, CCR3 and mainly CCR5. Here, we evaluated the role of CCR5 on traffic of leukocytes in the brain microvasculature, cellular and cytokines profile in a severe form of herpetic encephalitis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 33% |
Student > Master | 3 | 14% |
Other | 2 | 10% |
Lecturer | 1 | 5% |
Professor | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 24% |
Immunology and Microbiology | 4 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 29% |