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Phage display as a promising approach for vaccine development

Overview of attention for article published in Journal of Biomedical Science, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#29 of 856)
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

news
2 news outlets
twitter
6 tweeters

Citations

dimensions_citation
100 Dimensions

Readers on

mendeley
253 Mendeley
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Title
Phage display as a promising approach for vaccine development
Published in
Journal of Biomedical Science, September 2016
DOI 10.1186/s12929-016-0285-9
Pubmed ID
Authors

Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi, Jafar Majidi

Abstract

Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 253 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Switzerland 1 <1%
Unknown 251 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 49 19%
Student > Master 44 17%
Student > Ph. D. Student 41 16%
Researcher 26 10%
Student > Doctoral Student 13 5%
Other 35 14%
Unknown 45 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 72 28%
Agricultural and Biological Sciences 40 16%
Immunology and Microbiology 33 13%
Medicine and Dentistry 9 4%
Chemistry 9 4%
Other 38 15%
Unknown 52 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2020.
All research outputs
#1,255,711
of 19,396,073 outputs
Outputs from Journal of Biomedical Science
#29
of 856 outputs
Outputs of similar age
#26,559
of 285,026 outputs
Outputs of similar age from Journal of Biomedical Science
#1
of 2 outputs
Altmetric has tracked 19,396,073 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 856 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,026 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them