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Phage display as a promising approach for vaccine development

Overview of attention for article published in Journal of Biomedical Science, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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2 news outlets
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5 X users

Citations

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159 Dimensions

Readers on

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320 Mendeley
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Title
Phage display as a promising approach for vaccine development
Published in
Journal of Biomedical Science, September 2016
DOI 10.1186/s12929-016-0285-9
Pubmed ID
Authors

Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi, Jafar Majidi

Abstract

Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Switzerland 1 <1%
Unknown 318 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 53 17%
Student > Ph. D. Student 46 14%
Student > Master 46 14%
Researcher 33 10%
Student > Doctoral Student 14 4%
Other 40 13%
Unknown 88 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 86 27%
Agricultural and Biological Sciences 42 13%
Immunology and Microbiology 35 11%
Medicine and Dentistry 12 4%
Chemistry 10 3%
Other 39 12%
Unknown 96 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2020.
All research outputs
#1,852,788
of 25,374,647 outputs
Outputs from Journal of Biomedical Science
#70
of 1,101 outputs
Outputs of similar age
#32,035
of 330,424 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 14 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.