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Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Overview of attention for article published in Chinese Medicine, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 660)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

news
2 news outlets
blogs
2 blogs
twitter
2 X users
facebook
1 Facebook page
googleplus
2 Google+ users
video
1 YouTube creator

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
47 Mendeley
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Title
Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
Published in
Chinese Medicine, September 2016
DOI 10.1186/s13020-016-0114-9
Pubmed ID
Authors

Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie, Wenzhe Ma

Abstract

Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by searching the PubMed, Web of Science and China National Knowledge Infrastructure databases. The content of this review is based on studies reported in the literature pertaining to the chemical components or anti-cancer effects of GpM up until the beginning of August, 2016. This search of the literature revealed that more than 230 compounds have been isolated from GpM, and that most of these compounds (189) were saponins, which are also known as gypenosides. All of the remaining compounds were classified as sterols, flavonoids or polysaccharides. Various extracts and fractions of GpM, as well as numerous pure compounds isolated from this herb exhibited inhibitory activity towards the proliferation of cancer cells in vitro and in vivo. Furthermore, the results of several clinical studies have shown that GpM formula could have potential curative effects on cancer. Multiple mechanisms of action have been proposed regarding the anti-cancer activities of GpM, including cell cycle arrest, apoptosis, inhibition of invasion and metastasis, inhibition of glycolysis and immunomodulating activities.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 15%
Student > Bachelor 6 13%
Student > Master 5 11%
Student > Ph. D. Student 4 9%
Student > Doctoral Student 2 4%
Other 5 11%
Unknown 18 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 17%
Biochemistry, Genetics and Molecular Biology 7 15%
Medicine and Dentistry 7 15%
Engineering 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 2 4%
Unknown 19 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2023.
All research outputs
#1,160,591
of 25,374,647 outputs
Outputs from Chinese Medicine
#12
of 660 outputs
Outputs of similar age
#21,102
of 330,838 outputs
Outputs of similar age from Chinese Medicine
#2
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 660 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.