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Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study

Overview of attention for article published in BMC Medicine, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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1 news outlet
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14 X users
facebook
1 Facebook page
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1 YouTube creator

Citations

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134 Dimensions

Readers on

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136 Mendeley
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Title
Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
Published in
BMC Medicine, September 2016
DOI 10.1186/s12916-016-0693-4
Pubmed ID
Authors

Layal Chaker, Symen Ligthart, Tim I. M. Korevaar, Albert Hofman, Oscar H. Franco, Robin P. Peeters, Abbas Dehghan

Abstract

The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence. Cox-models were used to investigate the association of TSH and FT4 with diabetes and progression from prediabetes to diabetes. Multivariable models were adjusted for age, sex, high-density lipoprotein cholesterol, and glucose at baseline, amongst others. During a mean follow-up of 7.9 years, 798 diabetes cases occurred. Higher TSH levels were associated with a higher diabetes risk (hazard ratio [HR] 1.13; 95 % confidence interval [CI], 1.08-1.18, per logTSH), even within the reference range of thyroid function (HR 1.24; 95 % CI, 1.06-1.45). Higher FT4 levels were associated with a lower diabetes risk amongst all participants (HR 0.96; 95 % CI, 0.93-0.99, per 1 pmol/L) and in participants within the reference range of thyroid function (HR 0.96; 95 % CI, 0.92-0.99). The risk of progression from prediabetes to diabetes was higher with low-normal thyroid function (HR 1.32; 95 % CI, 1.06-1.64 for TSH and HR 0.91; 95 % CI, 0.86-0.97 for FT4). Absolute risk of developing diabetes type 2 in participants with prediabetes decreased from 35 % to almost 15 % with higher FT4 levels within the normal range. Low and low-normal thyroid function are risk factors for incident diabetes, especially in individuals with prediabetes. Future studies should investigate whether screening for and treatment of (subclinical) hypothyroidism is beneficial in subjects at risk of developing diabetes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Unknown 135 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 13%
Student > Bachelor 16 12%
Student > Doctoral Student 12 9%
Student > Ph. D. Student 11 8%
Researcher 10 7%
Other 31 23%
Unknown 38 28%
Readers by discipline Count As %
Medicine and Dentistry 53 39%
Biochemistry, Genetics and Molecular Biology 6 4%
Nursing and Health Professions 6 4%
Agricultural and Biological Sciences 5 4%
Unspecified 5 4%
Other 21 15%
Unknown 40 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2022.
All research outputs
#1,844,620
of 24,413,320 outputs
Outputs from BMC Medicine
#1,288
of 3,764 outputs
Outputs of similar age
#32,708
of 327,949 outputs
Outputs of similar age from BMC Medicine
#28
of 63 outputs
Altmetric has tracked 24,413,320 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,764 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.0. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,949 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.