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Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution

Overview of attention for article published in Virology Journal, February 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
2 tweeters
patent
2 patents

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
48 Mendeley

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Title
Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution
Published in
Virology Journal, February 2013
DOI 10.1186/1743-422x-10-50
Pubmed ID
23394344
Authors

Lin Yang, Xiao

Abstract

Adeno-associated virus (AAV) is an important vector system for human gene therapy. Although use of AAV serotypes can result in efficient myocardial gene transfer, improvements in the transduction efficiency and specificity are still required. As a method for artificial modification and selection of gene function, directed evolution has been used for diverse applications in genetic engineering of enzymes and proteins. Since 2000, pioneering work has been performed on directed evolution of viral vectors. We further attempted to evolve the AAV using DNA shuffling and in vivo biopanning in a mouse model. An AAVM41 mutant was characterized, which was found to have improved transduction efficiency and specificity in myocardium, an attribute unknown for any natural AAV serotypes. This review focuses on the development of AAV vector for cardiac gene transfer, the history of directed evolution of viral vectors, and our creation of a cardiotropic AAV, which might have implications for the future design and application of viral vectors.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 29%
Researcher 9 19%
Student > Master 7 15%
Other 4 8%
Student > Bachelor 4 8%
Other 6 13%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 40%
Biochemistry, Genetics and Molecular Biology 11 23%
Medicine and Dentistry 5 10%
Neuroscience 3 6%
Chemistry 2 4%
Other 3 6%
Unknown 5 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2020.
All research outputs
#3,099,854
of 17,389,828 outputs
Outputs from Virology Journal
#282
of 2,566 outputs
Outputs of similar age
#43,744
of 257,861 outputs
Outputs of similar age from Virology Journal
#22
of 222 outputs
Altmetric has tracked 17,389,828 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,566 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,861 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 222 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.

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