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Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

Overview of attention for article published in BMC Genomics, February 2013
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Title
Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages
Published in
BMC Genomics, February 2013
DOI 10.1186/1471-2164-14-92
Pubmed ID
Authors

Richard P Hull, Prashant K Srivastava, Zelpha D’Souza, Santosh S Atanur, Fatima Mechta-Grigoriou, Laurence Game, Enrico Petretto, H Terence Cook, Timothy J Aitman, Jacques Behmoaras

Abstract

The oxidative burst is one of the major antimicrobial mechanisms adopted by macrophages. The WKY rat strain is uniquely susceptible to experimentally induced macrophage-dependent crescentic glomerulonephritis (Crgn). We previously identified the AP-1 transcription factor JunD as a determinant of macrophage activation in WKY bone marrow-derived macrophages (BMDMs). JunD is over-expressed in WKY BMDMs and its silencing reduces Fc receptor-mediated oxidative burst in these cells.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Netherlands 1 2%
Romania 1 2%
Unknown 56 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 31%
Researcher 17 29%
Student > Master 5 8%
Student > Doctoral Student 4 7%
Student > Bachelor 2 3%
Other 10 17%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 47%
Biochemistry, Genetics and Molecular Biology 13 22%
Immunology and Microbiology 5 8%
Medicine and Dentistry 5 8%
Computer Science 1 2%
Other 3 5%
Unknown 4 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2013.
All research outputs
#18,809,260
of 23,310,485 outputs
Outputs from BMC Genomics
#8,255
of 10,742 outputs
Outputs of similar age
#225,789
of 290,548 outputs
Outputs of similar age from BMC Genomics
#271
of 358 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,742 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 358 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.