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An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity

Overview of attention for article published in Virology Journal, February 2013
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Title
An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity
Published in
Virology Journal, February 2013
DOI 10.1186/1743-422x-10-52
Pubmed ID
Authors

Juan C Zapata, Bhawna Poonia, Joseph Bryant, Harry Davis, Eugene Ateh, Lanea George, Oswald Crasta, Yan Zhang, Tom Slezak, Crystal Jaing, C David Pauza, Marco Goicochea, Dmitry Moshkoff, Igor S Lukashevich, Maria S Salvato

Abstract

Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs pathognomonic for arenavirus disease. ML29 is a reassortant between Lassa and Mopeia viruses that causes a transient infection in non-human primates and confers sterilizing protection from lethal Lassa viral challenge. However, since the LHF endemic area of West Africa also has high HIV seroprevalence, it is important to determine whether vaccination could be safe in the context of HIV infection.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Nigeria 1 2%
Switzerland 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 17%
Student > Ph. D. Student 10 15%
Student > Master 9 14%
Student > Bachelor 8 12%
Student > Postgraduate 4 6%
Other 7 11%
Unknown 17 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 21%
Medicine and Dentistry 12 18%
Biochemistry, Genetics and Molecular Biology 8 12%
Immunology and Microbiology 4 6%
Nursing and Health Professions 2 3%
Other 7 11%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2016.
All research outputs
#15,263,666
of 22,696,971 outputs
Outputs from Virology Journal
#1,938
of 3,030 outputs
Outputs of similar age
#185,178
of 287,465 outputs
Outputs of similar age from Virology Journal
#40
of 70 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,030 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.