Title |
An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity
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Published in |
Virology Journal, February 2013
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DOI | 10.1186/1743-422x-10-52 |
Pubmed ID | |
Authors |
Juan C Zapata, Bhawna Poonia, Joseph Bryant, Harry Davis, Eugene Ateh, Lanea George, Oswald Crasta, Yan Zhang, Tom Slezak, Crystal Jaing, C David Pauza, Marco Goicochea, Dmitry Moshkoff, Igor S Lukashevich, Maria S Salvato |
Abstract |
Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs pathognomonic for arenavirus disease. ML29 is a reassortant between Lassa and Mopeia viruses that causes a transient infection in non-human primates and confers sterilizing protection from lethal Lassa viral challenge. However, since the LHF endemic area of West Africa also has high HIV seroprevalence, it is important to determine whether vaccination could be safe in the context of HIV infection. |
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Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Nigeria | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 64 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 17% |
Student > Ph. D. Student | 10 | 15% |
Student > Master | 9 | 14% |
Student > Bachelor | 8 | 12% |
Student > Postgraduate | 4 | 6% |
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Unknown | 17 | 26% |
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Immunology and Microbiology | 4 | 6% |
Nursing and Health Professions | 2 | 3% |
Other | 7 | 11% |
Unknown | 19 | 29% |