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Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

Overview of attention for article published in BMC Cancer, January 2013
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1 X user
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1 Facebook page

Citations

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43 Dimensions

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38 Mendeley
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Title
Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells
Published in
BMC Cancer, January 2013
DOI 10.1186/1471-2407-13-41
Pubmed ID
Authors

Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Helmout Modjtahedi

Abstract

Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferation of pancreatic cancer cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Unknown 36 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Ph. D. Student 9 24%
Student > Master 7 18%
Other 2 5%
Student > Doctoral Student 2 5%
Other 2 5%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 10 26%
Agricultural and Biological Sciences 9 24%
Biochemistry, Genetics and Molecular Biology 7 18%
Engineering 2 5%
Chemistry 1 3%
Other 1 3%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2013.
All research outputs
#14,745,370
of 22,696,971 outputs
Outputs from BMC Cancer
#3,661
of 8,253 outputs
Outputs of similar age
#175,732
of 282,282 outputs
Outputs of similar age from BMC Cancer
#59
of 96 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,253 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,282 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.