Title |
Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals
|
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Published in |
Retrovirology, February 2013
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DOI | 10.1186/1742-4690-10-19 |
Pubmed ID | |
Authors |
Yoshimi Enose-Akahata, Anna Abrams, Raya Massoud, Izabela Bialuk, Kory R Johnson, Patrick L Green, Elizabeth M Maloney, Steven Jacobson |
Abstract |
Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects. HTLV-1 basic leucine zipper factor (HBZ) gene has a critical role in HTLV-1 infectivity and the development of ATL and HAM/TSP. However, little is known about the immune response against HBZ in HTLV-1-infected individuals. In this study, we examined antibody responses against HBZ in serum/plasma samples from 436 subjects including HTLV-1 seronegative donors, asymptomatic carriers (AC), ATL, and HAM/TSP patients using the luciferase immunoprecipitation system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 48 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 20% |
Student > Bachelor | 10 | 20% |
Student > Master | 6 | 12% |
Student > Ph. D. Student | 5 | 10% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 16% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 18% |
Immunology and Microbiology | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 12% |
Unknown | 6 | 12% |