Title |
Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line
|
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Published in |
Cancer Cell International, February 2013
|
DOI | 10.1186/1475-2867-13-14 |
Pubmed ID | |
Authors |
Ling Wang, Fubiao Kang, Jie Li, Jing Zhang, Baoen Shan |
Abstract |
Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation of NF-κB signaling. The NF-κB p65/RelA subunit may play a role in cell death through the activation of anti-apoptotic target genes including the inhibitor of apoptosis (IAP) and Bcl-2 families, and inhibition of protein kinase B/Akt. The aim of the present study was to investigate p65 as the potential target of celecoxib treatment and determine whether p65 overexpression can override the inhibitory effect of celecoxib on NF-κB activity and affect cell survival. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Croatia | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 24% |
Student > Master | 4 | 24% |
Student > Bachelor | 2 | 12% |
Researcher | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 24% |
Psychology | 2 | 12% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 24% |