Increased levels of #GDF15 are linked to disease severity in #HFrEF, but what if the increase is drug induced as seen by metformin? #SGLT2i increased circulating GDF15 levels in HFrEF after 12-weeks of follow-up. @CardResearchOuh @CopCard @SDCOdense https
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https://t.co/rrZlXptOoG SGLT2 inhibitors increase circulating GDF15 levels but only by about 10%. Much less than metformin, which ~doubles the levels
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The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker) https://t.co/Bai0tHjzOb #cardiac https://t.co/4Im2v00hn2
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The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker) https://t.co/dEvozNEWqS https://t.co/MlRFKUP3Qb