Title |
Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts
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Published in |
Respiratory Research, February 2013
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DOI | 10.1186/1465-9921-14-21 |
Pubmed ID | |
Authors |
Anna-Karin Larsson-Callerfelt, Oskar Hallgren, Annika Andersson-Sjöland, Lena Thiman, Johan Björklund, Josefine Kron, Kristian Nihlberg, Leif Bjermer, Claes-Göran Löfdahl, Gunilla Westergren-Thorsson |
Abstract |
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin and its effect on fibroblast activity and ECM production, and in particular collagen I and the collagen-associated proteoglycans biglycan and decorin. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 27% |
Student > Bachelor | 5 | 19% |
Student > Master | 3 | 12% |
Researcher | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 4 | 15% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 27% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Medicine and Dentistry | 4 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 4 | 15% |
Unknown | 5 | 19% |