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Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline

Overview of attention for article published in BMC Medicine, October 2016
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  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

1 policy source
4 tweeters


47 Dimensions

Readers on

65 Mendeley
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Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline
Published in
BMC Medicine, October 2016
DOI 10.1186/s12916-016-0699-y
Pubmed ID

A. C. de Kat, Y. T. van der Schouw, M. J. C. Eijkemans, G. C. Herber-Gast, J. A. Visser, W. M. M. Verschuren, F. J. M. Broekmans


Anti-Müllerian hormone (AMH) is currently used as an ovarian reserve marker for individualized fertility counseling, but very little is known of individual AMH decline in women. This study assessed whether the decline trajectory of AMH is uniform for all women, and whether baseline age-specific AMH levels remain consistently high or low during this trajectory. A total of 3326 female participants from the population-based Doetinchem Cohort Study were followed with five visits over a 20-year period. Baseline age was 40 ± 10 years with a range of 20-59 years. AMH was measured in 12,929 stored plasma samples using the picoAMH assay (AnshLabs). Decline trajectories of AMH were studied with both chronological age and reproductive age, i.e., time to menopause. Multivariable linear mixed effects models characterized the individual AMH decline trajectories. The overall rate of AMH decline accelerated after 40 years of age. Mixed models with varying age-specific AMH levels and decline rates provided the significantly best fit to the data, indicating that the fall in AMH levels over time does not follow a fixed pattern for individual women. AMH levels remained consistent along individual trajectories of age, with an intraclass correlation coefficient (ICC) of 0.87. The ICC of 0.32 for AMH trajectories with time to menopause expressed the large variation in AMH levels at a given time before the menopause. The differences between low and high age-specific AMH levels remained distinguishable, but became increasingly smaller with increasing chronological and reproductive age. This is the first study to characterize individual AMH decline over a long time period and broad age range. The varying AMH decline rates do not support the premise of a uniform AMH decline trajectory. Although age-specific AMH levels remain consistently high or low with increasing age, the converging trajectories and variance of AMH levels at a given time before menopause shed doubt on the added value of AMH to represent individualized reproductive age.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Student > Bachelor 11 17%
Student > Ph. D. Student 8 12%
Student > Doctoral Student 6 9%
Student > Postgraduate 5 8%
Other 11 17%
Unknown 11 17%
Readers by discipline Count As %
Medicine and Dentistry 17 26%
Biochemistry, Genetics and Molecular Biology 10 15%
Agricultural and Biological Sciences 5 8%
Nursing and Health Professions 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 8 12%
Unknown 19 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2019.
All research outputs
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Outputs from BMC Medicine
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Outputs of similar age
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Outputs of similar age from BMC Medicine
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Altmetric has tracked 17,362,547 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,703 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,705 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them