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Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis

Overview of attention for article published in BMC Psychiatry, October 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
3 news outlets
twitter
57 tweeters
wikipedia
3 Wikipedia pages

Citations

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96 Dimensions

Readers on

mendeley
224 Mendeley
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Title
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis
Published in
BMC Psychiatry, October 2016
DOI 10.1186/s12888-016-1049-5
Pubmed ID
Authors

Varuni Asanka de Silva, Chathurie Suraweera, Suhashini S. Ratnatunga, Madhubashinee Dayabandara, Nimali Wanniarachchi, Raveen Hanwella

Abstract

Most antipsychotics are associated with weight gain and other metabolic complications. Several randomized trials have shown metformin to be effective, but this still hasn't been included in clinical guidelines on managing antipsychotic induced weight gain. All double blind placebo controlled trials assessing the efficacy of metformin in the treatment of antipsychotic induced weight gain were included. Cochrane Central Register of Controlled Trials (CENTRAL) and MEDLINE were searched for the period January 2000-December 2015. Meta-analysis was carried out using the random effects model. Meta analysis of 12 published studies with a total of 743 patients found that in patients treated with antipsychotics, metformin treatment resulted in significantly better anthropometric and metabolic parameters than placebo. The mean change in weight was -3.27 kg (95 % CI -4.66 to -1.89) (Z = 4.64, p < 0.001). Metformin compared to placebo resulted in significant reduction in BMI [-1.13 kg/m(2) (95 % CI -1.61 to -0.66)] and insulin resistance index [-1.49 (95 % CI -2.40 to -0.59)] but not fasting blood sugar [-2.48 mg/dl (95 % CI -5.54 to 0.57]. This meta-analysis confirms that metformin is effective in treating antipsychotic induced weight gain in patients with schizophrenia or schizoaffective disorder.

Twitter Demographics

The data shown below were collected from the profiles of 57 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 <1%
Unknown 223 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 32 14%
Researcher 30 13%
Student > Bachelor 29 13%
Student > Ph. D. Student 19 8%
Student > Postgraduate 16 7%
Other 53 24%
Unknown 45 20%
Readers by discipline Count As %
Medicine and Dentistry 90 40%
Nursing and Health Professions 15 7%
Pharmacology, Toxicology and Pharmaceutical Science 13 6%
Psychology 12 5%
Neuroscience 11 5%
Other 27 12%
Unknown 56 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2022.
All research outputs
#533,158
of 22,046,823 outputs
Outputs from BMC Psychiatry
#121
of 4,506 outputs
Outputs of similar age
#11,731
of 293,745 outputs
Outputs of similar age from BMC Psychiatry
#1
of 1 outputs
Altmetric has tracked 22,046,823 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,506 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them