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Non-Pain-Related CRF1 Activation in the Amygdala Facilitates Synaptic Transmission and Pain Responses

Overview of attention for article published in Molecular Pain, January 2013
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Title
Non-Pain-Related CRF1 Activation in the Amygdala Facilitates Synaptic Transmission and Pain Responses
Published in
Molecular Pain, January 2013
DOI 10.1186/1744-8069-9-2
Pubmed ID
Authors

Guangchen Ji, Yu Fu, Hita Adwanikar, Volker Neugebauer

Abstract

Corticotropin-releasing factor (CRF) plays an important role in affective states and disorders. CRF is not only a "stress hormone" but also a neuromodulator outside the hypothalamic-pituitary-adrenocortical (HPA) axis. The amygdala, a brain center for emotions, is a major site of extrahypothalamic expression of CRF and its G-protein-coupled receptors. Our previous studies showed that endogenous activation of CRF1 receptors in an arthritis pain model contributes to amygdala hyperactivity and pain-related behaviors. Here we examined the synaptic and behavioral effects of CRF in the amygdala of normal animals in the absence of tissue injury or disease.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
France 1 1%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 27%
Student > Bachelor 12 17%
Researcher 8 11%
Professor 7 10%
Student > Master 7 10%
Other 11 15%
Unknown 7 10%
Readers by discipline Count As %
Neuroscience 17 24%
Agricultural and Biological Sciences 17 24%
Medicine and Dentistry 16 23%
Psychology 7 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 3 4%
Unknown 7 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2013.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Molecular Pain
#372
of 669 outputs
Outputs of similar age
#193,611
of 288,991 outputs
Outputs of similar age from Molecular Pain
#28
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.