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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer’s disease
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|---|---|
| Published in |
Alzheimer's Research & Therapy, September 2016
|
| DOI | 10.1186/s13195-016-0204-z |
| Pubmed ID | |
| Authors |
Laure Saint-Aubert, Ove Almkvist, Konstantinos Chiotis, Rita Almeida, Anders Wall, Agneta Nordberg |
| Abstract |
The recent development of tau-specific positron emission tomography (PET) tracers has allowed in vivo quantification of regional tau deposition and offers the opportunity to monitor the progression of tau pathology along with cognitive impairment. In this study, we investigated the relationships of cerebral tau deposition ([(18)F]THK5317-PET) and metabolism ([(18)F]FDG-PET) with concomitant cognitive function in patients with probable Alzheimer's disease (AD). Nine patients diagnosed with AD dementia and 11 with prodromal AD (mild cognitive impairment, amyloid-positive on [(11)C]PiB-PET) were included in this study. All patients underwent PET scans using each tracer, as well as episodic memory and global cognition assessment. Linear models were used to investigate the association of regional [(18)F]THK5317 retention and [(18)F]FDG uptake with cognition. The possible mediating effect of local metabolism on the relationship between tau deposition and cognitive performance was investigated using mediation analyses. Significant negative associations were found between [(18)F]THK5317 regional retention, mainly in temporal regions, and both episodic memory and global cognition. Significant positive associations were found between [(18)F]FDG regional uptake and cognition. The association of [(18)F]FDG with global cognition was regionally more extensive than that of [(18)F]THK5317, while the opposite was observed with episodic memory, suggesting that [(18)F]THK5317 retention might be more sensitive than [(18)F]FDG regional uptake to early cognitive impairment. Finally, [(18)F]FDG uptake had a mediating effect on the relationship between [(18)F]THK5317 retention in temporal regions and global cognition. These findings suggest a mediating role for local glucose metabolism in the observed association between in vivo tau deposition and concomitant cognitive impairment in AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 21% |
| Student > Ph. D. Student | 10 | 12% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 15 | 18% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 27% |
| Medicine and Dentistry | 15 | 18% |
| Psychology | 8 | 9% |
| Agricultural and Biological Sciences | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 26 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2016.
All research outputs
#3,133,627
of 22,890,496 outputs
Outputs from Alzheimer's Research & Therapy
#804
of 1,236 outputs
Outputs of similar age
#55,836
of 322,600 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#7
of 13 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,236 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.