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Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2016
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1 tweeter
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1 video uploader

Citations

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30 Dimensions

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67 Mendeley
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Title
Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats
Published in
BMC Complementary Medicine and Therapies, August 2016
DOI 10.1186/s12906-016-1303-x
Pubmed ID
Authors

Kazim Sahin, Cemal Orhan, Fatih Akdemir, Mehmet Tuzcu, Hasan Gencoglu, Nurhan Sahin, Gaffari Turk, Ismet Yilmaz, Ibrahim H. Ozercan, Vijaya Juturu

Abstract

Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-κB, Nrf2, and HO-1 in reproductive tissues. Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups. The extract groups were treated orally either with Mucuna, Tribulus or Ashwagandha (300 mg/kg b.w.) for 8 weeks. All of the extracts were found to be significantly effective in sexual functioning and antioxidant capacity and Tribulus showed the highest effectiveness. Serum testosterone levels significantly increased in Tribulus and Ashwagandha groups in comparison to control group. Tribulus was able to reduce the levels of NF-κB and increase the levels of Nrf2 and HO-1 to a much greater extent than Mucuna and Ashwagandha. These results demonstrate for the first time that Mucuna, Tribulus and Ashwagandha supplementation improves sexual function in male rats via activating Nrf2/ HO-1 pathway while inhibiting the NF-κB levels. Moreover, Tribulus terrestris extract was found to be more bioavailable from Ashwagandha extract followed by Mucuna extract. Schematic representation of the mode of action of some aphrodisiac herbal extracts to improve sexual functions.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 22%
Student > Ph. D. Student 7 10%
Researcher 5 7%
Student > Bachelor 4 6%
Other 4 6%
Other 14 21%
Unknown 18 27%
Readers by discipline Count As %
Medicine and Dentistry 11 16%
Pharmacology, Toxicology and Pharmaceutical Science 10 15%
Veterinary Science and Veterinary Medicine 6 9%
Biochemistry, Genetics and Molecular Biology 5 7%
Agricultural and Biological Sciences 4 6%
Other 6 9%
Unknown 25 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2022.
All research outputs
#14,612,940
of 22,489,892 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,739
of 3,303 outputs
Outputs of similar age
#166,756
of 288,368 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#1
of 1 outputs
Altmetric has tracked 22,489,892 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,303 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,368 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them