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Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells

Overview of attention for article published in BMC Genomics, January 2013
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1 tweeter
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Citations

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Title
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
Published in
BMC Genomics, January 2013
DOI 10.1186/1471-2164-14-105
Pubmed ID
Authors

Sarah R Herlofsen, Jan Christian Bryne, Torill Høiby, Li Wang, Robbyn Issner, Xiaolan Zhang, Michael J Coyne, Patrick Boyle, Hongcang Gu, Leonardo A Meza-Zepeda, Philippe Collas, Tarjei S Mikkelsen, Jan E Brinchmann

Abstract

For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene expression and extracellular matrix synthesis have been extensively studied, but the epigenomic modifications underlying these changes have not been described. To this end we performed whole-genome chromatin immunoprecipitation and deep sequencing to quantify six histone modifications, reduced representation bisulphite sequencing to quantify DNA methylation and mRNA microarrays to quantify gene expression before and after 7 days of chondrogenic differentiation of MSCs in an alginate scaffold. To add to the clinical relevance of our observations, the study is based on primary bone marrow-derived MSCs from four donors, allowing us to investigate inter-individual variations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 1 1%
Unknown 94 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 29%
Researcher 20 21%
Student > Master 8 8%
Student > Bachelor 6 6%
Professor 5 5%
Other 15 15%
Unknown 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 34%
Biochemistry, Genetics and Molecular Biology 25 26%
Medicine and Dentistry 11 11%
Engineering 6 6%
Physics and Astronomy 1 1%
Other 4 4%
Unknown 17 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2013.
All research outputs
#9,906,321
of 12,373,620 outputs
Outputs from BMC Genomics
#5,682
of 7,313 outputs
Outputs of similar age
#98,785
of 141,635 outputs
Outputs of similar age from BMC Genomics
#22
of 26 outputs
Altmetric has tracked 12,373,620 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,313 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,635 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.