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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide map of quantified epigenetic changes during in vitrochondrogenic differentiation of primary human mesenchymal stem cells
|
|---|---|
| Published in |
BMC Genomics, February 2013
|
| DOI | 10.1186/1471-2164-14-105 |
| Pubmed ID | |
| Authors |
Sarah R Herlofsen, Jan Christian Bryne, Torill Høiby, Li Wang, Robbyn Issner, Xiaolan Zhang, Michael J Coyne, Patrick Boyle, Hongcang Gu, Leonardo A Meza-Zepeda, Philippe Collas, Tarjei S Mikkelsen, Jan E Brinchmann |
| Abstract |
For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene expression and extracellular matrix synthesis have been extensively studied, but the epigenomic modifications underlying these changes have not been described. To this end we performed whole-genome chromatin immunoprecipitation and deep sequencing to quantify six histone modifications, reduced representation bisulphite sequencing to quantify DNA methylation and mRNA microarrays to quantify gene expression before and after 7 days of chondrogenic differentiation of MSCs in an alginate scaffold. To add to the clinical relevance of our observations, the study is based on primary bone marrow-derived MSCs from four donors, allowing us to investigate inter-individual variations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| United States | 1 | <1% |
| Unknown | 106 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 28% |
| Researcher | 20 | 18% |
| Student > Bachelor | 11 | 10% |
| Student > Master | 8 | 7% |
| Professor | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 20 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 30% |
| Biochemistry, Genetics and Molecular Biology | 27 | 25% |
| Medicine and Dentistry | 12 | 11% |
| Engineering | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2013.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from BMC Genomics
#8,135
of 11,244 outputs
Outputs of similar age
#235,060
of 309,585 outputs
Outputs of similar age from BMC Genomics
#113
of 164 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,585 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.