Title |
The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report
|
---|---|
Published in |
BMC Cancer, January 2006
|
DOI | 10.1186/1471-2407-6-7 |
Pubmed ID | |
Authors |
Jürgen C Becker, Roland Houben, Claudia S Vetter, Eva B Bröcker |
Abstract |
Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA) as a promising treatment for atopic dermatitis, it has been approved in more than 30 additional countries, including numerous European Union member nations. Moreover, in the current clinical routine the use of this drug is no longer restricted to the approved indication, but has been extended to a wide variety of inflammatory skin diseases including some with the potential of malignant transformation. So far, the side-effects reported from the topical use of tacrolimus have been relatively minor (e.g. burning, pruritus, erythema). Recently, however, the FDA reviewed the safety of topical tacrolimus, which resulted in a warning that the use of calcineurin inhibitors may be associated with an increased risk of cancer. |
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