Title |
Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
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Published in |
Journal of Hematology & Oncology, September 2016
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DOI | 10.1186/s13045-016-0310-1 |
Pubmed ID | |
Authors |
Zhiwu Jiang, Manman Deng, Xinru Wei, Wei Ye, Yiren Xiao, Simiao Lin, Suna Wang, Baiheng Li, Xin Liu, Gong Zhang, Peilong Lai, Jianyu Weng, Donghai Wu, Haijia Chen, Wei, Yuguo Ma, Yangqiu Li, Pentao Liu, Xin Du, Duanqing Pei, Yao, Bing Xu, Peng Li |
Abstract |
The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 18% |
Researcher | 3 | 18% |
Student > Doctoral Student | 1 | 6% |
Professor | 1 | 6% |
Student > Master | 1 | 6% |
Other | 3 | 18% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 18% |
Agricultural and Biological Sciences | 2 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Other | 3 | 18% |
Unknown | 6 | 35% |