Title |
Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress
|
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Published in |
BMC Ecology and Evolution, February 2013
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DOI | 10.1186/1471-2148-13-50 |
Pubmed ID | |
Authors |
Alejandra Rodríguez-Verdugo, Brandon S Gaut, Olivier Tenaillon |
Abstract |
Beneficial mutations play an essential role in bacterial adaptation, yet little is known about their fitness effects across genetic backgrounds and environments. One prominent example of bacterial adaptation is antibiotic resistance. Until recently, the paradigm has been that antibiotic resistance is selected by the presence of antibiotics because resistant mutations confer fitness costs in antibiotic free environments. In this study we show that it is not always the case, documenting the selection and fixation of resistant mutations in populations of Escherichia coli B that had never been exposed to antibiotics but instead evolved for 2000 generations at high temperature (42.2°C). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 27% |
France | 1 | 9% |
United Kingdom | 1 | 9% |
Unknown | 6 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 36% |
Members of the public | 3 | 27% |
Practitioners (doctors, other healthcare professionals) | 3 | 27% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 1% |
Belgium | 2 | <1% |
France | 2 | <1% |
United States | 2 | <1% |
Estonia | 2 | <1% |
Germany | 1 | <1% |
Unknown | 287 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 67 | 22% |
Student > Master | 48 | 16% |
Researcher | 46 | 15% |
Student > Bachelor | 39 | 13% |
Student > Doctoral Student | 16 | 5% |
Other | 33 | 11% |
Unknown | 50 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 118 | 39% |
Biochemistry, Genetics and Molecular Biology | 53 | 18% |
Medicine and Dentistry | 16 | 5% |
Immunology and Microbiology | 15 | 5% |
Environmental Science | 9 | 3% |
Other | 30 | 10% |
Unknown | 58 | 19% |