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Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits

Overview of attention for article published in Molecular Brain, October 2016
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Title
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits
Published in
Molecular Brain, October 2016
DOI 10.1186/s13041-016-0270-y
Pubmed ID
Authors

Lin Cui, Lin Cui, Wei Sun, Ming Yu, Nan Li, Li Guo, Huating Gu, Yu Zhou

Abstract

Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses that share cognitive impairments in common, including schizophrenia, bipolar disorder and major depression. Here we report that DISC1 L100P homozygous mutant shows normal anxiety- and depression-like behavior, but impaired object recognition which is prevented by administration of atypical antipsychotic drug clozapine. Ca(2+) image analysis reveals suppression of glutamate-evoked elevation of cytoplasmic [Ca(2+)] in L100P hippocampal slices. L100P mutant slices exhibit decreased excitatory synaptic transmission (sEPSCs and mEPSCs) in dentate gyrus (DG) and impaired long-term potentiation in the CA1 region of the hippocampus. L100P mutation does not alter proteins expression of the excitatory synaptic markers, PSD95 and synapsin-1; neither does it changes dendrites morphology of primary cultured hippocampal neurons. Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 24%
Student > Bachelor 8 18%
Student > Doctoral Student 5 11%
Researcher 4 9%
Student > Postgraduate 4 9%
Other 8 18%
Unknown 5 11%
Readers by discipline Count As %
Psychology 13 29%
Neuroscience 12 27%
Medicine and Dentistry 7 16%
Agricultural and Biological Sciences 4 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 2 4%
Unknown 5 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2016.
All research outputs
#6,456,179
of 8,508,684 outputs
Outputs from Molecular Brain
#354
of 454 outputs
Outputs of similar age
#175,720
of 252,525 outputs
Outputs of similar age from Molecular Brain
#8
of 11 outputs
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So far Altmetric has tracked 454 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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