Title |
Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants
|
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Published in |
Environmental Health, October 2016
|
DOI | 10.1186/s12940-016-0180-6 |
Pubmed ID | |
Authors |
Daniele Mandrioli, Fiorella Belpoggi, Ellen K. Silbergeld, Melissa J. Perry |
Abstract |
Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 17% |
Student > Doctoral Student | 6 | 9% |
Researcher | 6 | 9% |
Student > Ph. D. Student | 5 | 8% |
Professor | 4 | 6% |
Other | 11 | 17% |
Unknown | 23 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 18% |
Medicine and Dentistry | 9 | 14% |
Environmental Science | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 6 | 9% |
Unknown | 27 | 41% |