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Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations

Overview of attention for article published in Clinical Epigenetics, October 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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10 tweeters
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1 Wikipedia page

Citations

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47 Dimensions

Readers on

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128 Mendeley
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Title
Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations
Published in
Clinical Epigenetics, October 2016
DOI 10.1186/s13148-016-0276-4
Pubmed ID
Authors

Jing Xue, Sarah A. Schoenrock, William Valdar, Lisa M. Tarantino, Folami Y. Ideraabdullah

Abstract

Environmental perturbation of epigenetic mechanisms is linked to a growing number of diseases. Characterizing the role environmental factors play in modifying the epigenome is important for disease etiology. Vitamin D is an essential nutrient affecting brain, bone, heart, immune and reproductive health. Vitamin D insufficiency is a global issue, and the role in maternal and child health remains under investigation. We used Collaborative Cross (CC) inbred mice to characterize the effect of maternal vitamin D depletion on offspring phenotypic and epigenetic outcomes at imprinted domains (H19/Igf2, Snrpn, Dlk1/Gtl2, and Grb10) in the soma (liver) and germline (sperm). We assessed outcomes in two generations of offspring to determine heritability. We used reciprocal crosses between lines CC001/Unc and CC011/Unc to investigate parent of origin effects. Maternal vitamin D deficiency led to altered body weight and DNA methylation in two generations of offspring. Loci assayed in adult liver and sperm were mostly hypomethylated, but changes were few and small in effect size (<7 % difference on average). There was no change in total expression of genes adjacent to methylation changes in neonatal liver. Methylation changes were cell type specific such that changes at IG-DMR were present in sperm but not in liver. Some methylation changes were distinct between generations such that methylation changes at the H19ICR in second-generation liver were not present in first-generation sperm or liver. Interestingly, some diet-dependent changes in body weight and methylation were seemingly influenced by parent of origin such that reciprocal crosses exhibited inverse effects. These findings demonstrate that maternal vitamin D status plays a role in determining DNA methylation state in the germline and soma. Detection of methylation changes in the unexposed second-generation demonstrates that maternal vitamin D depletion can have long-term effects on the epigenome of subsequent generations. Differences in vitamin D-dependent epigenetic state between cell types and generations indicate perturbation of the epigenetic landscape rather than a targeted, locus-specific effect. While the biological importance of these subtle changes remains unclear, they warrant an investigation of epigenome-wide effects of maternal vitamin D depletion.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Netherlands 1 <1%
Unknown 125 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 30 23%
Student > Bachelor 20 16%
Student > Ph. D. Student 17 13%
Student > Master 12 9%
Researcher 10 8%
Other 20 16%
Unknown 19 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 44 34%
Agricultural and Biological Sciences 25 20%
Medicine and Dentistry 16 13%
Nursing and Health Professions 6 5%
Social Sciences 6 5%
Other 8 6%
Unknown 23 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2020.
All research outputs
#2,799,652
of 17,921,525 outputs
Outputs from Clinical Epigenetics
#169
of 990 outputs
Outputs of similar age
#54,293
of 278,829 outputs
Outputs of similar age from Clinical Epigenetics
#3
of 9 outputs
Altmetric has tracked 17,921,525 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 990 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.