Title |
Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment
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Published in |
BMC Complementary Medicine and Therapies, February 2013
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DOI | 10.1186/1472-6882-13-42 |
Pubmed ID | |
Authors |
Celso A R A Costa, Thaís C Cury, Bruna O Cassettari, Regina K Takahira, Jorge C Flório, Mirtes Costa |
Abstract |
The current treatments for anxiety disorders and depression have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in these disorders. Citrus aurantium was chosen based on ethnopharmacological data because traditional medicine refers to the Citrus genus as useful in diminishing the symptoms of anxiety or insomnia, and C. aurantium has more recently been proposed as an adjuvant for antidepressants. In the present work, we investigated the biological activity underlying the anxiolytic and antidepressant effects of C. aurantium essential oil (EO), the putative mechanism of the anxiolytic-like effect, and the neurochemical changes in specific brain structures of mice after acute treatment. We also monitored the mice for possible signs of toxicity after a 14-day treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 50% |
Switzerland | 1 | 8% |
Canada | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Unknown | 129 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 12% |
Student > Master | 15 | 12% |
Student > Ph. D. Student | 13 | 10% |
Researcher | 11 | 8% |
Student > Doctoral Student | 11 | 8% |
Other | 28 | 22% |
Unknown | 36 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 19% |
Agricultural and Biological Sciences | 19 | 15% |
Medicine and Dentistry | 13 | 10% |
Nursing and Health Professions | 6 | 5% |
Veterinary Science and Veterinary Medicine | 4 | 3% |
Other | 21 | 16% |
Unknown | 42 | 32% |