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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency
|
|---|---|
| Published in |
Respiratory Research, February 2013
|
| DOI | 10.1186/1465-9921-14-25 |
| Pubmed ID | |
| Authors |
Stephanie Korn, Marisa Hübner, Matthias Jung, Maria Blettner, Roland Buhl |
| Abstract |
ABSTRACT: BACKGROUND: Vitamin D has effects on the innate and adaptive immune system. In asthmatic children low vitamin D levels are associated with poor asthma control, reduced lung function, increased medication intake, and exacerbations. Little is known about vitamin D in adult asthma patients or its association with asthma severity and control. METHODS: Clinical parameters of asthma control and 25-hydroxyvitamin D (25(OH)D) serum concentrations were evaluated in 280 adult asthma patients (mean +/- SD: 45.0 +/- 13.8 yrs., 40% male, FEV1 74.9 +/- 23.4%, 55% severe, 51% uncontrolled). RESULTS: 25(OH)D concentrations in adult asthmatics were low (25.6 +/-11.8 ng/ml) and vitamin D insufficiency or deficiency (vitamin D <30 ng/ml) was common (67%). 25(OH)D levels were related to asthma severity (intermittent: 31.1 +/- 13.0 ng/ml, mild: 27.3 +/- 11.9 ng/ml, moderate: 26.5 +/- 12.0 ng/ml, severe: 24.0 +/- 11.8 ng/ml, p = 0.046) and control (controlled: 29.5 +/- 12.5 ng/ml, partly controlled 25.9 +/- 10.8 ng/ml, uncontrolled: 24.2 +/- 11.8 ng/ml, p = 0.030). The frequency of vitamin D insufficiency or deficiency was significantly higher in patients with severe or uncontrolled asthma and was associated with a lower FEV1 (vitamin D <30 vs. >=30 ng/ml 2.3 +/- 0.9 L vs. 2.7 +/- 1.0 L, p = 0.006), higher levels of exhaled NO (45 +/- 46 ppb vs. 31 +/- 37 ppb, p = 0.023), a higher BMI (28.3 +/- 6.2 vs. 25.1 +/- 3.9, p < 0.001), and sputum eosinophilia (5.1 +/- 11.8% vs. 0.5 +/- 1.0%, p = 0.005). The use of oral corticosteroids or sputum eosinophilia was associated with a 20% or 40% higher risk of vitamin D insufficiency or deficiency. CONCLUSIONS: 25(OH)D levels below 30 ng/ml are common in adult asthma and most pronounced in patients with severe and/or uncontrolled asthma, supporting the hypothesis that improving suboptimal vitamin D status might be effective in prevention and treatment of asthma. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 14% |
| United States | 2 | 14% |
| South Africa | 1 | 7% |
| Brazil | 1 | 7% |
| Unknown | 8 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 79% |
| Practitioners (doctors, other healthcare professionals) | 3 | 21% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Germany | 1 | <1% |
| Malaysia | 1 | <1% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 107 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 19% |
| Student > Master | 17 | 15% |
| Researcher | 10 | 9% |
| Other | 8 | 7% |
| Student > Postgraduate | 8 | 7% |
| Other | 20 | 18% |
| Unknown | 29 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 40% |
| Agricultural and Biological Sciences | 14 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Other | 7 | 6% |
| Unknown | 33 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2016.
All research outputs
#1,706,809
of 22,699,621 outputs
Outputs from Respiratory Research
#145
of 2,720 outputs
Outputs of similar age
#14,374
of 192,954 outputs
Outputs of similar age from Respiratory Research
#2
of 32 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,720 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.