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Medicinal importance of grapefruit juice and its interaction with various drugs

Overview of attention for article published in Nutrition Journal, October 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

news
1 news outlet
twitter
9 tweeters
facebook
3 Facebook pages
wikipedia
5 Wikipedia pages
video
1 video uploader

Citations

dimensions_citation
80 Dimensions

Readers on

mendeley
188 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
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Title
Medicinal importance of grapefruit juice and its interaction with various drugs
Published in
Nutrition Journal, October 2007
DOI 10.1186/1475-2891-6-33
Pubmed ID
Authors

Jawad Kiani, Sardar Z Imam

Abstract

Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P - 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P - glycoprotein pump, found in the brush border of the intestinal wall which transports many of these cytochrome P - 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. By inhibiting these enzyme systems, grapefruit juice alters the pharmacokinetics of a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on the calcium channel antagonist and the statin group of drugs. In the case of many drugs, the increased serum concentration has been found to be associated with increased frequency of dose dependent adverse effects. In this review, we have discussed the phytochemistry of grapefruit juice, the various drugs involved in the drug - grapefruit juice reaction with their mechanisms of action and have presented the clinical implications of these interactions.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Germany 1 <1%
Canada 1 <1%
Nigeria 1 <1%
United States 1 <1%
Unknown 181 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 43 23%
Other 24 13%
Student > Master 24 13%
Researcher 20 11%
Student > Ph. D. Student 16 9%
Other 27 14%
Unknown 34 18%
Readers by discipline Count As %
Medicine and Dentistry 50 27%
Agricultural and Biological Sciences 31 16%
Pharmacology, Toxicology and Pharmaceutical Science 24 13%
Biochemistry, Genetics and Molecular Biology 10 5%
Nursing and Health Professions 9 5%
Other 23 12%
Unknown 41 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2021.
All research outputs
#1,278,059
of 21,467,161 outputs
Outputs from Nutrition Journal
#351
of 1,392 outputs
Outputs of similar age
#9,790
of 170,552 outputs
Outputs of similar age from Nutrition Journal
#1
of 1 outputs
Altmetric has tracked 21,467,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,392 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,552 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them