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Infection with Plasmodium berghei ookinetes alters protein expression in the brain of Anopheles albimanus mosquitoes

Overview of attention for article published in Parasites & Vectors, October 2016
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Title
Infection with Plasmodium berghei ookinetes alters protein expression in the brain of Anopheles albimanus mosquitoes
Published in
Parasites & Vectors, October 2016
DOI 10.1186/s13071-016-1830-9
Pubmed ID
Authors

Alejandro Alvarado-Delgado, Guillermo Perales Ortiz, Ángel T. Tello-López, Sergio Encarnación, Renaud Conde, Ángel G. Martínez-Batallar, Ken Moran-Francia, Humberto Lanz-Mendoza

Abstract

The behaviour of Anopheles spp. mosquitoes, vectors for Plasmodium parasites, plays a crucial role in the propagation of malaria to humans. Consequently, it is important to understand how the behaviour of these mosquitoes is influenced by the interaction between the brain and immunological status. The nervous system is intimately linked to the immune and endocrine systems. There is evidence that the malaria parasite alters the function of these systems upon infecting the mosquito. Although there is a complex molecular interplay between the Plasmodium parasite and Anopheles mosquito, little is known about the neuronal alteration triggered by the parasite invasion. The aim of this study was to analyse the modification of the proteomic profile in the An. albimanus brain during the early phase of the Plasmodium berghei invasion. At 24 hours of the P. berghei invasion, the mosquito brain showed an increase in the concentration of proteins involved in the cellular metabolic pathway, such as ATP synthase complex alpha and beta, malate dehydrogenase, alanine transaminase, enolase and vacuolar ATP synthase. There was also a rise in the levels of proteins with neuronal function, such as calreticulin, mitofilin and creatine kinase. Concomitantly, the parasite invasion repressed the expression of synapse-associated proteins, including enolyl CoA hydratase, HSP70 and ribosomal S60 proteins. Identification of upregulated and downregulated protein expression in the mosquito brain 24 hours after Plasmodium invaded the insect midgut paves the way to better understanding the regulation of the neuro-endocrine-immune system in an insect model during parasite infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Student > Bachelor 4 17%
Researcher 4 17%
Other 3 13%
Professor > Associate Professor 2 8%
Other 3 13%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 6 25%
Biochemistry, Genetics and Molecular Biology 5 21%
Agricultural and Biological Sciences 4 17%
Immunology and Microbiology 3 13%
Energy 1 4%
Other 0 0%
Unknown 5 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2016.
All research outputs
#14,275,152
of 22,893,031 outputs
Outputs from Parasites & Vectors
#2,826
of 5,476 outputs
Outputs of similar age
#182,141
of 320,020 outputs
Outputs of similar age from Parasites & Vectors
#48
of 100 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,476 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,020 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.