Title |
Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain
|
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Published in |
BMC Veterinary Research, October 2016
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DOI | 10.1186/s12917-016-0854-x |
Pubmed ID | |
Authors |
Zhenguang Li, Yanliang He, Xiaoqin Xu, Xue Leng, Shufen Li, Yongjun Wen, Fengxue Wang, Mingqi Xia, Shipeng Cheng, Hua Wu |
Abstract |
Porcine reproductive and respiratory syndrome (PRRS) remains a major threat to swine industry all over the world. The aim of this study was to investigate the mechanism of pathogenesis and immune responses caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). All piglets experimentally infected with a HP-PRRSV TJ strain virus developed typical clinical signs of PRRS. The percentages of CD3(+), CD4(+), and CD8(+) lymphocytes significantly decreased in the infected group as compared to the uninfected control animals (p < 0.01). Total WBC dropped in the infected animals during the experiment. The level of ELISA antibody against PRRSV increased in 7-10 days after infection and then started to decline. Pathological observations demonstrated various degree lesions, bleeding and necrosis in the lungs of the infected piglets. These results clearly indicated that HP-PRRSV TJ strain infection would activate host humoral immune response at the early period post infection and cause severe pathological damages on lungs and inhibit cellular immune response after infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 28% |
Student > Master | 5 | 20% |
Researcher | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Doctoral Student | 1 | 4% |
Other | 0 | 0% |
Unknown | 6 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 14 | 56% |
Agricultural and Biological Sciences | 4 | 16% |
Immunology and Microbiology | 2 | 8% |
Unknown | 5 | 20% |