Title |
Extending the Developmental Origins of Health and Disease theory: does paternal diet contribute to breast cancer risk in daughters?
|
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Published in |
Breast Cancer Research, October 2016
|
DOI | 10.1186/s13058-016-0760-y |
Pubmed ID | |
Authors |
Stephanie Romanus, Patrick Neven, Adelheid Soubry |
Abstract |
The Developmental Origins of Health and Disease (DOHaD) theory focuses on the consequences of periconceptional and in utero exposures. A wide range of environmental conditions during early development are now being investigated as a driving force for epigenetic disruptions that enhance disease risk in later life, including cardiovascular, metabolic, endocrine, and mental disorders and even breast cancer. Most studies involve mother-child dyads, with less focus on environmental influences through the father. Over the last few years, however, new insights have been introduced on paternal effects and the plasticity of the epigenome of developing sperm cells have been proposed to underlie inheritable changes from ancestral exposures. The field is evolving rapidly and study results from animal models are promising. Although caution should be taken in translating animal data to humans, epidemiological findings also suggest a prominent role of the father. Therefore, we here propose an extension to the DOHaD theory to include also paternally inheritable influences. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 17% |
Student > Master | 9 | 16% |
Student > Bachelor | 8 | 14% |
Student > Doctoral Student | 6 | 10% |
Researcher | 4 | 7% |
Other | 5 | 9% |
Unknown | 16 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Agricultural and Biological Sciences | 5 | 9% |
Nursing and Health Professions | 4 | 7% |
Social Sciences | 2 | 3% |
Other | 10 | 17% |
Unknown | 20 | 34% |