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Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma

Overview of attention for article published in BMC Medicine, October 2016
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Title
Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma
Published in
BMC Medicine, October 2016
DOI 10.1186/s12916-016-0711-6
Pubmed ID
Authors

Baoping Guo, Hong Cen, Xiaohong Tan, Qing Ke

Abstract

The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. A comprehensive search to identify relevant articles was performed in PubMed, Embase, and Google Scholar on January 31, 2016. Using the fixed effect or random effects model of DerSimonian and Laird, hazard ratios (HR) or odds ratios (OR) with 95 % confidence intervals (CIs) were used as the effect size estimate. Twenty-two eligible studies with a total of 2959 patients were identified. Our analysis indicated that a high density of CD68(+) TAMs in the tumor microenvironment of adult cHL predicted poor overall survival (OS) (HR: 2.41; 95 % CI, 1.92-3.03), shorter progression-free survival (PFS) (HR: 1.78; 95 % CI, 1.45-2.18), and poor disease-specific survival (HR: 2.71; 95 % CI, 1.38-5.29). High density of CD163(+) TAMs in the tumor microenvironment of adult cHL also predicted poor OS (HR: 2.75; 95 % CI, 1.58-4.78) and poor PFS (HR: 1.66; 95 % CI, 1.22-2.27). In addition, we demonstrated that a high density of either CD68(+) or CD163(+) TAMs was associated with the presence of Epstein-Barr virus in neoplastic cells (ORCD68: 3.13; 95 % CI, 2.02-4.84; ORCD163: 2.88; 95 % CI, 1.55-5.34). A high density of either CD68(+) or CD163(+) TAMs tend to be associated with a more advanced clinical stage (ORCD68: 1.25; 95 % CI, 0.93-1.67; OR CD163: 1.19; 95 % CI, 0.86-1.63), B-symptoms (ORCD68: 1.35; 95 % CI, 0.90-2.01; ORCD163: 2.19; 95 % CI, 0.96-5.03), higher International Prognostic Factors Project Score (ORCD68: 1.20; 95 % CI, 0.67-2.15; ORCD163: 2.00; 95 % CI, 0.92-4.35), and bulky disease (ORCD68: 1.47; 95 % CI, 0.88-2.47; ORCD163: 1.19; 95 % CI, 0.72-1.96). Our analyses suggest that a high density of either CD68(+) or CD163(+) TAMs is a robust predictor of adverse outcomes in adult cHL. Increased TAMs should be taken into account to further improve prognostic stratification and the planning of appropriate therapeutic strategies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Student > Master 10 18%
Researcher 9 16%
Student > Postgraduate 4 7%
Lecturer 3 5%
Other 10 18%
Unknown 10 18%
Readers by discipline Count As %
Medicine and Dentistry 26 46%
Biochemistry, Genetics and Molecular Biology 9 16%
Immunology and Microbiology 2 4%
Social Sciences 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 4%
Unknown 15 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2016.
All research outputs
#14,703,374
of 16,669,654 outputs
Outputs from BMC Medicine
#2,568
of 2,637 outputs
Outputs of similar age
#252,553
of 298,824 outputs
Outputs of similar age from BMC Medicine
#210
of 212 outputs
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