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Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

Overview of attention for article published in Infectious Agents and Cancer, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 222)
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
25 Mendeley
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Title
Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy
Published in
Infectious Agents and Cancer, June 2016
DOI 10.1186/s13027-016-0073-x
Pubmed ID
Authors

Martina Taborelli, Jerry Polesel, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Monica Battiston, Michele Spina, Francesco Di Raimondo, Antonio Pinto, Anna Crispo, Maria Grimaldi, Silvia Franceschi, Luigino Dal Maso, Diego Serraino

Abstract

Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg(+)) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc(+)) alone were not at increased NHL risk. Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 16%
Student > Doctoral Student 3 12%
Student > Bachelor 3 12%
Student > Ph. D. Student 3 12%
Lecturer 2 8%
Other 6 24%
Unknown 4 16%
Readers by discipline Count As %
Medicine and Dentistry 14 56%
Biochemistry, Genetics and Molecular Biology 3 12%
Nursing and Health Professions 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Sports and Recreations 1 4%
Other 1 4%
Unknown 4 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2016.
All research outputs
#1,261,295
of 8,534,300 outputs
Outputs from Infectious Agents and Cancer
#24
of 222 outputs
Outputs of similar age
#54,754
of 251,132 outputs
Outputs of similar age from Infectious Agents and Cancer
#1
of 5 outputs
Altmetric has tracked 8,534,300 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 222 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them