Interesting paper on CSF lactate but need to consider conc gradients relative to transporters (e.g. GLUTs, MCTs, etc). Glucose: blood to brain, 5:1 Lactate: brain to blood, 5:1 Ergo, lactate dumps to blood. Our paper in NHPs w/ plasma lactate & CSF
CSF lactate does not indicate biological or clinical disease severity in #Alzheimers. Large(r) (N = 312) study. CSF lactate levels were (loosely) associated with age and blood-brain barrier integrity, but not disease status. https://t.co/9zhhYjDRcI https:/
New article: Cerebrospinal fluid lactate levels along the Alzheimer's disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers https://t.co/9SnleACblq #alzheimers #neurology https://t.co/MwcoDS6PpB