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Porcine CD8αdim/-NKp46high NK cells are in a highly activated state

Overview of attention for article published in Veterinary Research, March 2013
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Title
Porcine CD8αdim/-NKp46high NK cells are in a highly activated state
Published in
Veterinary Research, March 2013
DOI 10.1186/1297-9716-44-13
Pubmed ID
Authors

Kerstin H Mair, Andrea Müllebner, Sabine E Essler, J Catharina Duvigneau, Anne K Storset, Armin Saalmüller, Wilhelm Gerner

Abstract

Natural Killer (NK) cells play a crucial role in the early phase of immune responses against various pathogens. In swine so far only little information about this lymphocyte population exists. Phenotypical analyses with newly developed monoclonal antibodies (mAbs) against porcine NKp46 recently revealed that in blood NKp46- and NKp46+ cells with NK phenotype exist with comparable cytotoxic properties. In spleen a third NKp46-defined population with NK phenotype was observed that was characterised by a low to negative CD8α and increased NKp46 expression. In the current study it is shown that this NKp46high phenotype was correlated with an increased expression of CD16 and CD27 compared to the CD8α+NKp46- and NKp46+ NK-cell subsets in spleen and blood. Additionally NKp46high NK cells expressed elevated levels of the chemokine receptor CXCR3 on mRNA level. Functional analyses revealed that splenic NKp46high NK cells produced much higher levels of Interferon-γ and Tumor Necrosis Factor-α upon stimulation with cytokines or phorbol-12-myristate-13-acetate/Ionomycin compared to the other two subsets. Furthermore, cross-linking of NKp46 by NKp46-specific mAbs led to a superior CD107a expression in the NKp46high NK cells, thus indicating a higher cytolytic capacity of this subset. Therefore porcine splenic NKp46high NK cells represent a highly activated subset of NK cells and may play a profound role in the immune surveillance of this organ.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 31%
Researcher 8 22%
Student > Master 5 14%
Student > Bachelor 3 8%
Professor > Associate Professor 2 6%
Other 2 6%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 31%
Immunology and Microbiology 6 17%
Medicine and Dentistry 5 14%
Biochemistry, Genetics and Molecular Biology 3 8%
Engineering 2 6%
Other 1 3%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2013.
All research outputs
#3,079,396
of 4,507,144 outputs
Outputs from Veterinary Research
#318
of 417 outputs
Outputs of similar age
#59,988
of 89,129 outputs
Outputs of similar age from Veterinary Research
#11
of 13 outputs
Altmetric has tracked 4,507,144 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.