Title |
Determination of dosage compensation of the mammalian X chromosome by RNA-seq is dependent on analytical approach
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Published in |
BMC Genomics, March 2013
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DOI | 10.1186/1471-2164-14-150 |
Pubmed ID | |
Authors |
Nathaniel K Jue, Michael B Murphy, Seth D Kasowitz, Sohaib M Qureshi, Craig J Obergfell, Sahar Elsisi, Robert J Foley, Rachel J O’Neill, Michael J O’Neill |
Abstract |
An enduring question surrounding sex chromosome evolution is whether effective hemizygosity in the heterogametic sex leads inevitably to dosage compensation of sex-linked genes, and whether this compensation has been observed in a variety of organisms. Incongruence in the conclusions reached in some recent reports has been attributed to different high-throughput approaches to transcriptome analysis. However, recent reports each utilizing RNA-seq to gauge X-linked gene expression relative to autosomal gene expression also arrived at diametrically opposed conclusions regarding X chromosome dosage compensation in mammals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 33% |
Germany | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Czechia | 1 | 2% |
Germany | 1 | 2% |
Unknown | 52 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 32% |
Researcher | 8 | 14% |
Student > Master | 8 | 14% |
Professor > Associate Professor | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 8 | 14% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 50% |
Biochemistry, Genetics and Molecular Biology | 19 | 34% |
Computer Science | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Neuroscience | 1 | 2% |
Other | 0 | 0% |
Unknown | 6 | 11% |