Title |
Characterization and differential expression of microRNAs in the ovaries of pregnant and non-pregnant goats (Capra hircus)
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Published in |
BMC Genomics, March 2013
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DOI | 10.1186/1471-2164-14-157 |
Pubmed ID | |
Authors |
Xiao-Dong Zhang, Yun-Hai Zhang, Ying-Hui Ling, Ya Liu, Hong-Guo Cao, Zong-Jun Yin, Jian-Ping Ding, Xiao-Rong Zhang |
Abstract |
Ovarian follicular development and hormone secretion are complex and coordinated biological processes which will usually be altered during pregnancy. Ovarian function is tightly regulated by a multitude of genes, and also by some specific miRNAs. It is necessary to identify the differentially expressed miRNAs in the ovaries of pregnant and non-pregnant mammals, in order to further understand the role of miRNA-mediated post-transcriptional regulation in mammalian reproduction. Here, we performed a comprehensive search for hircine miRNAs using two small RNA sequencing libraries prepared from the ovaries of pregnant and non-pregnant goats. |
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