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Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues

Overview of attention for article published in BMC Musculoskeletal Disorders, March 2013
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Title
Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues
Published in
BMC Musculoskeletal Disorders, March 2013
DOI 10.1186/1471-2474-14-85
Pubmed ID
Authors

Emma V A Raine, Andrew W Dodd, Louise N Reynard, John Loughlin

Abstract

The single nucleotide polymorphism (SNP) rs2615977 is associated with osteoarthritis (OA) and is located in intron 31 of COL11A1, a strong candidate gene for this degenerative musculoskeletal disease. Furthermore, the common non-synonymous COL11A1 SNP rs1676486 is associated with another degenerative musculoskeletal disease, lumbar disc herniation (LDH). rs1676486 is a C-T transition mediating its affect on LDH susceptibility by modulating COL11A1 expression. The risk T-allele of rs1676486 leads to reduced expression of the COL11A1 transcript, a phenomenon known as allelic expression imbalance (AEI). We were keen therefore to assess whether the effect that rs1676486 has on COL11A1 expression in LDH is also observed in OA and whether the rs2615977 association to OA also marked AEI.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Postgraduate 5 13%
Student > Master 4 10%
Student > Doctoral Student 3 8%
Lecturer > Senior Lecturer 3 8%
Other 7 18%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 10 26%
Agricultural and Biological Sciences 6 15%
Biochemistry, Genetics and Molecular Biology 5 13%
Immunology and Microbiology 2 5%
Nursing and Health Professions 1 3%
Other 2 5%
Unknown 13 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2013.
All research outputs
#20,184,694
of 22,699,621 outputs
Outputs from BMC Musculoskeletal Disorders
#3,611
of 4,028 outputs
Outputs of similar age
#171,413
of 195,228 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#84
of 91 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,028 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,228 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.