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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human tolerogenic DC-10: perspectives for clinical applications
|
|---|---|
| Published in |
Transplantation Research, September 2012
|
| DOI | 10.1186/2047-1440-1-14 |
| Pubmed ID | |
| Authors |
Giada Amodio, Silvia Gregori |
| Abstract |
Dendritic cells (DCs) are critically involved in inducing either immunity or tolerance. During the last decades efforts have been devoted to the development of ad hoc methods to manipulate DCs in vitro to enhance or stabilize their tolerogenic properties. Addition of IL-10 during monocyte-derived DC differentiation allows the induction of DC-10, a subset of human tolerogenic DCs characterized by high IL-10/IL-12 ratio and co-expression of high levels of the tolerogenic molecules HLA-G and immunoglobulin-like transcript 4. DC-10 are potent inducers of adaptive type 1 regulatory T cells, well known to promote and maintain peripheral tolerance. In this review we provide an in-depth comparison of the phenotype and mechanisms of suppression mediated by DC-10 and other known regulatory antigen-presenting cells currently under clinical development. We discuss the clinical therapeutic application of DC-10 as inducers of type 1 regulatory T cells for tailoring regulatory T-cell-based cell therapy, and the use of DC-10 as adoptive cell therapy for promoting and restoring tolerance in T-cell-mediated diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Panama | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 20% |
| Student > Ph. D. Student | 14 | 16% |
| Student > Doctoral Student | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 7 | 8% |
| Other | 16 | 19% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 22 | 26% |
| Agricultural and Biological Sciences | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 15 | 17% |
| Medicine and Dentistry | 14 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 17 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2019.
All research outputs
#6,922,951
of 22,701,287 outputs
Outputs from Transplantation Research
#12
of 39 outputs
Outputs of similar age
#50,964
of 172,151 outputs
Outputs of similar age from Transplantation Research
#3
of 5 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 39 research outputs from this source. They receive a mean Attention Score of 3.4. This one scored the same or higher as 27 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.