https://t.co/WGrdfomCka "CpG-rich young LTRs were found to be repressed by DNA methylation, while middle-aged LTRs were silenced mainly by posttranslational histone modifications such as H3K9me3"
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3,511 followers
https://t.co/WGrdfomCka "A recent study proposed a correlation between silencing mechanisms and the evolutionary age of HERVs."
3,511 followers
https://t.co/WGrdfomCka "Because the splicing and poly(A) addition signals of HERV are present in the antisense direction, HERV transcription in the opposite direction to that of the gene may be the least disruptive to mRNA synthesis"
3,511 followers
https://t.co/WGrdfomCka "In this case, the harmful HERV provirus within a transcription unit is subject to negative selection and disappears over the course of evolution"